phrI [2017-8-11 16:0:3]

response regulator aspartate phosphatase (RapI) regulator

locus: BSU05020

pI: 8.91

mw: 4.10 kDa

protein length: 39 aa

gene length: 117 bp

function: control of the transfer of the mobile genetic element ICEBs1

product: phosphatase (RapI) regulator

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.2|Mobile genetic elements] → [category|SW 5.2.1|ICEBs1]
• [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

Gene

Coordinates: 548,438 → 548,557

The protein

Catalyzed reaction/ biological activity

• binds [protein|A208B4564A50D7BE2630DE40E8FAAF3C16236EE4|RapI] and inhibits its activity, this results in contiuned repression of the genes for the transfer of the mobile genetic element ICEBs1 by [protein|DD1C8F3A4809785BD6A6047D39B42AB2C605E161|ImmR] [Pubmed|17511812]

Protein family

• phr family (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|A208B4564A50D7BE2630DE40E8FAAF3C16236EE4|rapI]-[gene|F3E14B772A5DA9073ED806A9ADDD9B64F0DFDD5B|phrI]
  description: [Pubmed|11466295]

  sigma factors

  • [protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH]: sigma factor, [Pubmed|11466295], in [regulon|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH regulon]
  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|11466295], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, [Pubmed|26582911], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]

  regulation

  • induced at high cell density ([SW|ComA]) [Pubmed|26582911]

• genes: [gene|F3E14B772A5DA9073ED806A9ADDD9B64F0DFDD5B|phrI]
  description: [Pubmed|11466295]

  regulation

  • induced at high cell density ([SW|ComA]) [Pubmed|26582911]

References

Reviews

• 24995588

Original publications

• 11466295,17511812,26582911